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Infertility is characterized as the inability to attain pregnancy following 12 months or longer of consistent unprotected sexual intercourse. Approximately 10 to 15 percent of couples experience infertility, often requiring the utilization of assisted reproductive techniques.

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Procedures:

Insemination (IUI)

IUI involves introducing cleaned and capacitated sperm into the uterus, representing one of the assisted reproductive techniques. This procedure enhances the likelihood of interaction between eggs and sperm within the uterine environment, thereby raising the probability of achieving pregnancy.

Candidacy for IUI:

How is IUI performed?

This procedure is conducted without anesthesia. It involves washing the semen in a specific manner to make the sperm fertile. Subsequently, the prepared sperm is transferred into the woman’s uterus through the vagina using a narrow tube. To enhance the chances of pregnancy, ovarian stimulating drugs are administered to increase the release of two or three eggs per cycle.
The sperm sample, obtained through masturbation, is submitted to the laboratory on the scheduled day. After washing and preparation in the laboratory, the sperm is stored until ready for injection. Using a catheter, the sperms are then injected into the uterus.
Post IUI, hospitalization is unnecessary, and the patient can resume regular activities without absolute rest. A pregnancy test is conducted two weeks after the procedure to determine its success.

How is IUI performed

What is the success rate of IUI operation?

The success rate of IUI is between 15% and 20% in each treatment cycle.

How much is a cycle of IUI?

IUI is an affordable fertility treatment. The expense of an IUI cycle varies based on factors like the country and clinic where the treatment is sought, as well as whether the procedure involves the male partner’s sperm or donated sperm.

IUI in Iran

Boasting over 70 dedicated fertility and infertility clinics, Iran provides state-of-the-art facilities and resources to assist couples facing infertility challenges in achieving parenthood. IUI stands out as a prevalent fertility treatment in the country, with success rates comparable to the best clinics globally.

In vitro fertilization (IVF)

In vitro fertilization (IVF) is a fertilization method to overcome infertility, in which an egg is united with sperm outside the body, typically in a laboratory setting. This entails overseeing and stimulating a woman’s ovulation, extracting one or more eggs from her ovaries, and allowing fertilization by sperm to occur in a culture medium within a laboratory.

What’s the difference between IUI and IVF?

Unlike IUI, where male sperm are introduced into the woman’s uterus through tubes, IVF involves the external combination of a female egg and male sperm in a laboratory setting. Following fertilization, the resulting embryo is then implanted into the woman’s uterus. IVF is employed in situations where conditions for sperm reaching the egg in the uterus are not met, such as closed uterine tubes, pelvic adhesions, low sperm count, and reduced sperm motility.

Candidacy for IVF:

How does it work?

The egg is extracted through the vagina using a needle under anesthesia, guided by vaginal ultrasound. The man’s sperm sample is obtained and processed in the andrology laboratory for use in IVF. Subsequently, the sperm and egg are positioned adjacent to each other in the embryology laboratory within a culture environment, facilitating the sperm to enter and fertilize the egg.
The resulting fertilized egg is termed an “embryo.” As the single-celled embryo divides, a multi-celled embryo forms. To enhance the likelihood of pregnancy, multiple embryos are occasionally implanted in the uterus, potentially resulting in multiple births.

Stages of the IVF procedure:

What is the success rate of IVF?

The effectiveness of IVF for each embryo transfer in fertility and infertility treatment centers is assessed based on factors such as the quality of the embryology laboratory, the precision of gynecologists in the treatment process, the condition of the sperm and egg, and the woman’s age. Success rates typically range between 20 and 30 percent under various circumstances.
In Iran, boasting over 70 specialized fertility clinics, the country is equipped with modern facilities to assist couples facing infertility challenges. IVF stands out as a prevalent fertility treatment in Iran, with a success rate reaching up to 50%, surpassing the average success rate of around 35% in other countries.

IVF in Iran

With more than 70 specialized fertility clinics, Iran has modern facilities and resources to help couples with infertility problems conceive a child.
IVF is one of the most common fertility treatments in Iran. The success rate of IVF in Iran has reached up to 50% being the highest among other countries (which have a success rate of about 35%)

Ovulation stimulation drugs

Ovulation induction is one of the infertility resolution methods which uses hormonal therapy to stimulate egg development and release, or ovulation.

How does it work?

Patients receive ovulation stimulation drugs following various protocols tailored to their age and condition. These drugs, either singly or in combination, precede the next phase of hormone therapy, which is egg retrieval. Ovulation stimulation causes the ovaries to enlarge and position near the vaginal wall, facilitating egg collection through vaginal puncture. The procedure, conducted under general or local anesthesia, involves ultrasound-guided observations. Using a long needle, the doctor pierces the follicles through the vagina, extracting eggs and follicular fluid. Mature eggs are then collected with a suction pump, monitored via ultrasound observations of the ovarian state on a television screen.
During egg collection, the patient’s spouse provides semen, which is then processed to isolate healthy and highly active sperm after washing and preparation. Depending on the sperm’s condition, it is introduced into the egg container. Following the doctor’s decision, embryos may be implanted in the uterus or frozen for future use.
Certainly, minimizing mental, emotional, and stressful situations can contribute to the operation’s success. Approximately 12 to 14 days post-embryo transfer, the patient’s blood is tested for HCG hormone levels, with an elevation serving as the initial indication of pregnancy.

What is the success rate?

The success rates, around 20% monthly, are comparable to those observed in fertile couples. Nevertheless, the fertility diagnosis and the woman’s age can influence the likelihood of success.

Sperm Donation

Candidacy for Sperm Donation?

The recommendation for sperm donation arises when the male’s sperm lacks sufficient quantity or quality to fertilize the woman’s egg. This approach is also suitable when semen analysis indicates azoospermia or the absence of sperm in the ejaculate. Generally, the physician advises the sperm donation method in the following conditions:

Choosing a Sperm Donor

To identify a suitable sperm donor, it is essential to establish specific criteria. Begin by examining key characteristics such as physical attributes (height, hair color, skin tone), family medical history (blood type, history of conditions like high blood pressure or diabetes), and occupation (e.g., artist, scientist, athlete). Determine the traits you desire for your baby. All this information is documented in each donor’s file at a fertility or infertility clinic.

While the majority of sperm donors remain anonymous, if anonymity is not desired, individuals can approach someone they know to be their sperm donor. Additionally, in certain cases, recipient couples may obtain more than one vial of their preferred donor’s sperm if they plan to have another child in the future.

Surrogacy and Ova Donation.

Conceiving a child may appear challenging for women who have undergone hysterectomies, faced diseases, or encountered structural womb issues preventing fetal implantation. However, thanks to scientific advancements and the utilization of surrogate wombs, many of these couples can now realize their dream of parenthood and work their way around the infertility problem.

How does it work?

The surrogacy method involves a surrogate mother carrying the couple’s fetus when traditional childbirth methods are not viable. In this process, the mother’s eggs are fertilized with the father’s sperm in a laboratory and implanted into a woman capable of carrying the child. The surrogate carries the fetus in her womb and, upon childbirth, legally hands over the child to the infertile couple as per a predetermined contract. Importantly, the newborn inherits the genetic characteristics of its parents, and the surrogate exerts no influence in this regard.

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